Gastric Cancer

Research results from Zhejiang University update understanding of gastric cancer

Published in Medical Devices and Surgical Technology Week, November 23rd, 2008

According to recent research from Hangzhou, People's Republic of China, "7-[(3-piperidyl)-1-propinyl]-camptothecin (CPT21) is a novel semi-synthetic water-soluble analogue of camptothecin. In this context, we assessed the anti-tumor activity of CPT21 both in vivo and in vitro and explored its molecular mechanism."

"We found that CPT21 presented a broad anti-tumor spectrum against ten cancer cell lines in vitro, and the IC50 values ranged from 0.1 to 12.0 mc M. CPT21 was also capable to interrupt the DNA topoisemerase I activity and caused DNA double strand breaks during DNA replication. Proportion of apoptotic SGC7901 cells induced by CPT21 showed a time- and...

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Source: Medical Devices and Surgical Technology Week (2008-11-23)

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