Life Sciences

Reports from M.J. Sinneggerbrauns et al highlight recent research in life sciences

Published in Medical Devices and Surgical Technology Week, March 29th, 2009

"The L-type calcium channel (LTCC) isoforms Ca(v)1.2 and Ca(v)1.3 display similar 1,4-dihydropyridine (DHP) binding properties and are both expressed in mammalian brain. Recent work implicates Cav1.3 channels as interesting drug targets, but no isoform-selective modulators exist," investigators in Innsbruck, Austria report.

"It is also unknown to what extent Ca(v)1.1 and Ca(v)1.4 contribute to L-type-specific DHP binding activity in brain. To address this question and to determine whether DHPs can discriminate between Ca(v)1.2 and Ca(v)1.3 binding pockets, we combined radioreceptor assays and quantitative polymerase chain reaction (qPCR). We bred double mutants...

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Source: Medical Devices and Surgical Technology Week (2009-03-29)

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