Life Sciences

Research from Y. Wu and co-authors provides new data about life sciences

Published in Medical Devices and Surgical Technology Week, September 27th, 2009

According to recent research published in the Journal of Biological Chemistry, "Bisretinoid adducts accumulate as lipofuscin in retinal pigment epithelial (RPE) cells of the eye and are implicated in the pathology of inherited and age-related macular degeneration. Characterization of the bisretinoids A2E and the all-trans-retinal dimer series has shown that these pigments form from reactions in photoreceptor cell outer segments that involve all-trans-retinal, the product of photoisomerization of the visual chromophore 11-cis-retinal."

"Here we have identified two related but previously unknown RPE lipofuscin compounds. By high performance liquid...

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Source: Medical Devices and Surgical Technology Week (2009-09-27)

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