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World Journal of Gastroenterology
Is duodenal biopsy necessary in celiac disease diagnosis for children and adults?
November 15th, 2009
Duodenal biopsy remains the gold standard for celiac disease (CD) diagnosis. However, it has several pitfalls and requires an invasive procedure in children. In the past few years, a more prominent role for a definitive diagnosis based solely on serology has been proposed. The predictive value of high levels of anti-tissue transglutaminase (tTG) antibodies has also been reported in retrospective CD cohorts. Based on these studies, some authors have proposed to start a gluten-free diet (GFD) for those patients with high tTG antibody levels, without duodenal biopsy. There is no agreement to start a GFD without biopsy to confirm mucosal atrophy. There are age-related differences in CD...
Source: Medical Devices & Surgical Technology Week (2009-11-15)
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