Published in Medical Imaging Business Week, July 29th, 2004
Human Hsp90, an important oncology target, is one of a class of proteins called chaperones, which function to facilitate the proper folding of other proteins. Many of the proteins Hsp90 helps to fold are themselves targets for anticancer drug development. Inhibition of Hsp90 disrupts the proper folding of these client proteins and thereby disrupts many of the pathways implicated in the growth of cancer.
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