Harvard University, U.S.
Enzyme-targeted fluorescent imaging probes on multiple antigenic peptide core have been developed
Published in Medical Imaging Law Weekly, September 19th, 2006
According to researchers writing in the Journal of Medicinal Chemistry, "Peptide dendrimers have a variety of applications in biology such as the vehicles for drug and gene delivery, molecular inhibitors, protein mimics, and synthetic vaccines. The multiple antigenic peptide (MAP) system is a well-known example of a discrete, dendrimeric scaffold. We explored a novel application of the MAP-based scaffold by designing molecular probes that fluoresce only after enzymatic treatment."
"The probes, which were synthesized on solid support,...
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