Monoclonal Antibodies

Research reports on monoclonal antibodies from C. Hagman and colleagues provide new insights

Published in Medical Imaging Law Weekly, April 8th, 2008

"The development of a quantification method for monoclonal antibodies in serum has been accomplished by high-performance liquid chromatography multiple reactions monitoring mass spectrometry. A human monoclonal antibody (HmAb) was used as the model protein for method development and validation," scientists writing in the journal Analytical Chemistry report.

"A peptide from the CDR3-region of its heavy chain was selected and used for quantifying the entire mAb. This signature peptide served as a template for the internal standard. Prior to mass spectrometric analysis approximately 50% of the total serum protein content was removed by albumin depletion. The...

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Source: Medical Imaging Law Weekly (2008-04-08)

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