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Biophysics

New technique will produce a better chromosome map

Published in Medical Imaging Week, May 26th, 2007

Researchers at the University of Illinois have developed a simple and economical technique for imaging and mapping fruit fly chromosomes. This new approach will enable them to construct the first accurate map of the chromosomes and tease out the secrets hidden in their stripes.

Their work appears online May 6 in advance of publication in the journal Nature Methods.

Fruit flies are well suited for chromosome studies because some of their cells contain gigantic, "polytene" chromosomes, each built up of more than 1,000 parallel copies of DNA strands. When stained, condensed, dark bands and lighter regions (interbands) give the chromosomes a striped...

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