Imaging

Scientists at Sungkyunkwan University, Department of Nuclear Medicine release new data on imaging

Published in Medical Imaging Week, July 28th, 2007

Researchers detail in "Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase," new data in imaging. According to recent research from Seoul, Korea, "Alzheimer's disease (AD) is characterized by reduced acetylcholinesterase (AChE) activity in the post-mortem tissues of AD patients. Therefore, AChE has been an attractive target for the diagnosis of AD."

"In the present study, 5,7-dihydro-3-[2-(1-(phenylmethyl)-4-piperidinyl)ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one (CP-118,954), a potent AChE inhibitor, was labelled with radioiodine and evaluated as an AChE imaging agent for SPECT. Radioiodine-labelled CP-118,954...

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Source: Medical Imaging Week (2007-07-28)

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