Pharmacokinetics
Research from M. Doubrovin and co-authors in the area of pharmacokinetics published
Published in Medical Imaging Week, February 20th, 2010
"Because of the recent development of an iodopyridopyrimidinone Abl protein kinase inhibitor (PKI), I-124-SKI-212230 (I-124-SKI230), we investigated the feasibility of a PET-based molecular imaging method for the direct visualization of Abl kinase expression and PKI treatment. In vitro pharmacokinetic properties, including specific and nonspecific binding of I-124-SKI230 to its Abl kinase target and interaction with other PKIs, were assessed in cell-free medium and chronic myelogenous leukemia (CML) cells overexpressing BCR-Abl (K562), in comparison with BT-474 cells that are low in Abl expression," scientists in the United States report.
"In a xenograft tumor model, we...
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Source: Medical Imaging Week (2010-02-20)
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