Lyme Disease

1990-'91 Missouri Rash Outbreak A False Alarm

Published in Medical Letter on the CDC and FDA, September 25th, 1995

A rash of suspected Lyme disease cases in Missouri remained unexplained after a recent retrospective case-control study. The results were not entirely unexpected, since the preponderance of Lyme disease cares are clustered in the northeastern United States.

Researchers suggested possible causes for the unexplained Missouri outbreak might include infection with a novel A. americanum-transmitted pathogen and an atypical toxic or immunologic reaction to tick-associated proteins.

CDC's Grant L. Campbell and colleagues investigated 45 Missouri outpatients with ring-shaped rashes meeting a surveillance case definition for erythema migrans and with...

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Source: Medical Letter on the CDC and FDA (1995-09-25)

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