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Prophylaxis

Ciprofloxacin/Pyrazinamide Useful in Preventing MDR-TB

Published in Medical Letter on the CDC and FDA, November 6th, 1995

Prophylaxis containing both ciprofloxacin and pyrazinamide should be considered for health care workers who are infected with multidrug resistant Mycobacterium tuberculosis, according to a report from Case Western Reserve University, Cleveland, Ohio.

Prophylactic therapy with isoniazid is the established regimen for those infected with drug-sensitive strains of M. tuberculosis, but in those presumed to be infected with resistant strains the appropriate course of preventive therapy is not clear.

Prophylaxis with ciprofloxacin, 750 mg twice daily, and pyrazinamide, 25 to 30 mg/kg per day in three divided doses for six to twelve months has...

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