TB/HIV Coinfection

Specific TB Activation May Be Linked to HIV Susceptibility

Published in Medical Letter on the CDC and FDA, April 1st, 1996

A pattern of non-specific activation during tuberculosis infection may be associated with enhanced susceptibility to HIV infection, according to a multicenter report conducted under the auspices of the U.S. Centers for Disease Control and Prevention.

Mycobacterium tuberculosis induces several immune alterations in humans. Blood monocytes from tuberculosis patients show signs of activation, whereas T-cell responses to mycobacterial antigens in vitro are sometimes very low.

"The latter phenomenon may be explained by active blood monocyte-mediated suppression and by intrinsic T-cell anergy," researcher G. Vanham and colleagues wrote...

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