Drug Resistance

530 and 912 Loops Not Critical in Streptomycin Resistance

Published in Medical Letter on the CDC and FDA, July 8th, 1996

The 530 loop and 912 loop regions of mycobacterial 16S rRNA appear to play only minor roles in resistance to the antituberculosis agent streptomycin, according to a report from the U.S. Centers for Disease Control and Prevention's (CDC) National Center for Infectious Diseases.

Inadequate treatment regimens and noncompliance on the part of patients are the most common reasons for the emergence of drug-resistant strains of tuberculosis.

"Scrutiny of treatment strategies has resulted in recommendations for inclusion of as many as three additional drugs to the standard three-drug regimen of isoniazid, rifampin and pyrazinamide," researcher Robert C....

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Source: Medical Letter on the CDC and FDA (1996-07-08)

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