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Plasmodium falciparum

More Ligands Seem to Be Involved in Cytoadherence

Published in Medical Letter on the CDC and FDA, February 24th, 1997

Sulfated glycoconjugates may be among the molecules that serve as Plasmodium falciparum-parasitized red cell receptors of microvascular endothelial cells.

In P. falciparum infection, human red cells parasitized with late trophozoites and schizonts (PRBC) adhere to the endothelium of postcapillary venules.

This cytoadherence, or sequestration, occurs mostly in the brain, liver, heart, lung, kidney, spleen, and small intestine, leading to malfunctioning of these organs, noted Lihua Xiao, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, and colleagues ("Plasmodium falciparum: Involvement of Additional Receptors...

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