Prophylaxis (TB)

Pyrazinamide/Ofloxacin Combo Useful for MDR-TB

Published in Medical Letter on the CDC and FDA, March 10th, 1997

The combination of pyrazinamide and ofloxacin appears to be effective preventive therapy for those exposed to multidrug resistant tuberculosis, according to macrophage studies.

Researchers including John Sbarbaro from the University of Colorado Health Sciences Center and Michael Iseman from Denver's National Jewish Center for Immunology and Respiratory Diseases examined three difference concentrations of ofloxacin in combination with pyrazinamide and determined that all three were active against the multidrug-resistant tuberculous bacilli ("Combined Effect of Pyrazinamide and Ofloxacin Within the Human Macrophage," Tubercle and Lung Disease, December...

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Source: Medical Letter on the CDC and FDA (1997-03-10)

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