Poliovirus
"Comparison of a Monoclonal Antibody-Based IgM Capture ELISA with a Neutralization Assay for Assessing Response to Trivalent Oral Poliovirus Vaccine."
Published in Medical Letter on the CDC and FDA, March 17th, 1997
According to the authors' abstract of an article published in Journal of Infectious Diseases, "Monoclone-based IgM capture ELISAs were developed for each of the three poliovirus serotypes and compared with a neutralization assay for detecting response to trivalent oral poliovirus vaccine among 224 infants. The IgM-based response rates were significantly higher than the neutralizing antibody-based rates: 958 versus 83% to poliovirus type 1, 99% versus 94% to poliovirus type 2, and 89% versus 59% to poliovirus type 3. IgM responses to the first vaccine dose were significantly associated between serotypes, suggesting that some of the discordance may reflect a heterotypic IgM response. ...
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