Published in Medical Letter on the CDC and FDA, April 21st, 1997
DEN hemorrhagic fever-DEN shock syndrome (DHF-DSS), the severe outcome of DEN virus infection, is sometimes accompanied by liver injury. Councilman bodies that have been observed in liver biopsies of case patients with DHF-DSS may correspond to hepatocytes in apoptosis, noted Philippe Marianneau and colleagues, Institut Pasteur, Paris, France.
Marianneau et al. performed a study to find whether a causal relationship exists between DEN virus replication and apoptosis and to identify the mechanisms by which DEN virus infection induces apoptotic cell death in...
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