"Antimony-Induced Alterations in Thiol Homeostasis and Adenine Nucleotide Status in Cultured Cardiac Myocytes."

According to the authors' abstract of an article published in Toxicology, "Cultured cardiac myocytes were exposed for up to 4 h to 50 and 100 (mu)M potassium antimonyl tartrate (PAT). After 4 h, 50 and 100 (mu)M PAT killed 14 and 33% respectively of the cardiac myocytes. PAT-induced alterations in both protein and nonprotein thiol homeostasis. Transient increases in oxidized glutathione disulfide (GSSG) levels were detected after cells were treated with 100 (mu)M PAT for 2 h. After 4 h, both concentrations of PAT significantly depleted reduced glutathione (GSH) levels. Protein thiols levels were also decreased after a 2-h exposure to 50 and 100 (mu)M PAT. Cells treated with 50 (mu)M...

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