Plasmodium falciparum
"Cytotoxic T Cell Reactivity and HLA-B35 Binding of the Variant Plasmodium falciparum Circumsporozoite Protein CD8+ CTL Epitope in Naturally Exposed Kenyan Adults."
Published in Medical Letter on the CDC and FDA, October 20th, 1997
According to the authors' abstract of an article published in European Journal of Immunology, "In this study, we have investigated the extent of natural polymorphism in the CD8+ cytotoxic T lymphocyte (CTL) determinant (amino acids 368-390) of circumsporozoite (CS) protein of Plasmodium falciparum field isolates from a holoendemic region of Kenya, and determined how this variation affects the CTL reactivities in clinically immune adults and binding specificities to human histocompatibility leukocyte antigen (HLA)-B35. Among the eight variant sequences that were found in this region, four were new and not seen in parasites from other geographical regions. When synthetic...
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