"Immunoregulatory Changes in Kawasaki Disease."

According to the authors' abstract of an article published in Clinical Immunology and Immunopathology, "Kawasaki disease (KD) is an acute vasculitis of unknown etiology, occurring in young children and treated with intravenous gamma globulin (MG) to prevent significant cardiac morbidity and mortality. We studied KD patients pre-and post-IVIG therapy and at >40 days posttherapy, additionally comparing them with matched pediatric control patients and parents. Using three-color flow cytometry, we examined immune changes in KD, especially previously unassessed markers of T-lymphocyte activation, memory, and adhesion. The percentage of cells positive for CD19, CD25, CD38, and CD71 was...

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