Cerebral Malaria (Pathogenesis)
Cytokine Changes Observed Only in Brains of Animals
Published in Medical Letter on the CDC and FDA, November 17th, 1997
A life-threatening complication of Plasmodium falciparum malaria, cerebral malaria (CM) remains poorly understood, and the pathogenesis of this condition remains controversial, despite almost 100 years of research, noted Veronica M. Jennings, Emory University, Atlanta, Georgia, and colleagues from the U.S. Centers for Disease Control and Prevention.
The discovery that murine CM caused by P. berghei ANKA and human CM both are characterized by the production of inflammatory cytokines, especially tumor necrosis factor alpha (TNF-(alpha)), has revived...
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