Endometrial Cancer
"Menopausal Hormone Use and Endometrial Cancer, by Tumor Grade and Invasion."
Published in Medical Letter on the CDC and FDA, March 9th, 1998
According to the authors' abstract of an article published in Epidemiology, "We analyzed data from a population based case-control study to investigate whether combined hormone replacement therapy influences the incidence of high-grade and -stage endometrial cancer. Subjects were women with epithelial endometrial cancer (N = 730) diagnosed during 1985-1991 and controls identified through random digit dialing (N = 1,002). Relative to hormone nonusers, women who took unopposed estrogens (mostly conjugated estrogens) for 3 or more years had a fivefold increase in the risk of tumors with myometrial invasion; the corresponding relative risk associated with combined therapy (estrogen and...
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