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Japanese Encephalitis

"Immunogenicity of Live Attenuated SA14-14-2 Japanese Encephalitis Vaccine - A Comparison of 1- and 3-Month Immunization Schedules."

Published in Medical Letter on the CDC and FDA, March 16th, 1998

According to the authors' abstract of an article published in Journal of Infectious Diseases, "Live attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been safe and effective in >100 million immunized children, but its current administration schedule of two doses given a year apart does not lend itself to inclusion in established Expanded Program of Immunization (EPI) schedules of childhood immunization. Immune responses to immunization at shorter intervals were compared in middle-school-aged children immunized with two doses separated by 1 month (n = 116) or 2.5 months (n = 115), Two vaccine lots were compared. Seroconversion to the vaccine was observed in 100% of vaccinees...

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