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Outbreak Investigation

Super-Virulent TB Strain May Hold Key to Vaccine

Published in Medical Letter on the CDC and FDA, March 16th, 1998

A super-virulent strain of tuberculosis which led to a recent outbreak along the Kentucky-Tennessee border may further the development of an improved TB vaccine.

The outbreak involved 21 cases of active tuberculosis and 311 tuberculin skin test conversions between 1994 and 1996. Murine studies conducted by the U.S. Centers for Disease Control and Prevention (CDC) showed the involved strain to be remarkably fast fast-growing ("An Outbreak Involving Extensive Transmission of a Virulent Strain of Mycobacterium tuberculosis," The New England Journal of Medicine, March 5, 1998;333(10):633-639).

The strain has been selected for the Mycobacterium...

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