Conference Coverage (Emerging Infectious Diseases)
Phase I Trials: Live Dengue Vaccines Safe, Immunogenic
Published in Medical Letter on the CDC and FDA, April 13th, 1998
There are four dengue serotypes. R. Edelman of the University of Maryland and colleagues created live, attenuated vaccines against each type by serial passage in primary dog kidney (PDK) cells.
Only one the 18 healthy volunteers receiving the vaccines developed a fever, and this was of much shorter duration and lower intensity (3 days, 102.1(degree)F maximum) than that seen in dengue fever.
"A tetravalent vaccine consisting of these four dengue strains will be tested in volunteers soon,"...
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