HHV-8
CDC Researchers Develop Peptide-Based EIA
Published in Medical Letter on the CDC and FDA, June 22nd, 1998
U.S. Centers for Disease Control and Prevention (CDC) researchers Chou-Pong Pau and colleagues mapped a dominant epitope within the HHV-8 ORF 65-encoded protein to an 8-amino-acid (aa) sequence (RKPPSGKK [aa 162 to 169]) by an amino acid replacement method ("Mapping and Serodiagnostic Application of a Dominant Epitope within the Human Herpesvirus 8 ORF 65-Encoded Protein," Journal of Clinical Microbiology, June 1998;36:1574-1577).
They used a 14-aa peptide (P4) encompassing this epitope as the antigen to develop an EIA for HHV-8 antibodies.
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