Published in Medical Letter on the CDC and FDA, October 5th, 1998
With the trial announced, Vertex is expanding the scope of the VX-497 development program to explore the potential antiviral activity of the compound, in addition to developing it as a drug for autoimmune indications. Vertex next plans to initiate a Phase II clinical trial in psoriasis, an autoimmune disease of the skin.
VX-497 is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a human enzyme that is essential for production of nucleotides - the building...
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