Drug Reactions

Endotoxin-Like Reactions Associated with Intravenous Gentamicin

Published in Medical Letter on the CDC and FDA, November 9th, 1998

Gentamicin adverse reactions are associated with Fujisawa gentamicin given once daily.

Since April 1998, hospitals in seven U.S. states have reported chills or rigors in 37 patients following the administration of intravenous gentamicin.

Gentamicin, an aminoglycoside antibiotic, is used to treat serious bacterial infections and can be given in multiple doses per day or as a single daily dose.

These adverse reactions appear to be associated with single daily dosing of gentamicin. The reactions appear to be self-limited and have not been associated with any deaths.

Although further studies are currently...

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Source: Medical Letter on the CDC and FDA (1998-11-09)

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