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Drug Resistance

Test Helps Doctors Pick AIDS Drugs

Published in Medical Letter on the CDC and FDA, February 14th, 2000

Doctors say they can improve the chance of successfully treating AIDS by measuring how each patient's virus stands up to the drugs intended to kill HIV.

Through evolution, HIV can grow resistant to any of the standard AIDS drugs, and often it is invulnerable to several at once. The specific combination of viral resistance varies from patient to patient. In theory, doctors can brew up the most potent AIDS drug cocktails for their patients if they know the strengths and vulnerabilities of the viruses they carry.

In the past, doctors have attempted to do this by checking the virus for the genetic mutations that make it impervious to various drugs. ...

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