Published in Medical Letter on the CDC and FDA, March 20th, 2000
"Two anionic fluorescein derivatives can be used for the simple and definitive localization of neuronal degeneration in brain tissue sections," according to L.C. Schmued and colleagues at the U.S. Food and Drug Administration ("Fluoro-Jade: Novel fluorochromes for detecting toxicant-induced neuronal degeneration," Toxicologic Pathology, January-February 2000;28(1):91-99).
Schmued's group reported that Flouro-Jade, a first-generation fluorescein derivative, was able to detect neuronal damage caused by numerous well-known substances,...
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