Immunology
HLA-DP4 defines a new supertype of peptide-binding specificity
Published in Medical Letter on the CDC and FDA, February 16th, 2003
According to recent research from France, "Among HLA-DP specificities, HLA-DP4 specificity involves at least two molecules, HLA-DPA1*0103/DPBI*0401 (DP401) and HLA-DPA1*0103/DPB1*0402 (DP402), which differ from each other by only three residues. Together, they are present worldwide at an allelic frequency of 20-60% and are the most abundant human HLA II alleles. Strikingly, the peptide-binding specificities of these molecules have never been investigated."
"Hence, in this study, we report the peptide-binding motifs of both molecules," stated Florence A. Castelli and collaborators at the Commissariat a l'Energie Atomique-Saclay, SEDAC Therapeutics, and the...
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