Tuberculosis Vaccine

Antigen 85A expression enhances immunogenicity to Mycobacterium tuberculosis

Published in Medical Letter on the CDC and FDA, March 9th, 2003

According to a study from the United States, "The immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A."

"pSINCP-85A was highly immunogenic in mice and gave enhanced long-term protection against M. tuberculosis compared with the conventional vector," reported Joanna R. Kirman and her colleagues at the National Institutes of Health, the Food and Drug Administration, and Chiron Corporation.

Kirman and her coauthors published the results of their study in...

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Source: Medical Letter on the CDC and FDA (2003-03-09)

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