New test of non-inferiority for anti-infective trials developed

According to a study from the United States, "This paper describes a new statistical test of non-inferiority in clinical trials of anti-infective medications. The test allows the inferiority limit, delta, to vary with the underlying success rates."

"The test is a simple modification of the standard fixed-delta test, and its parameters can be adjusted to yield the fixed-delta test, a test similar to the FDA's Points-to-Consider procedure, or a test with nearly constant power values over a range of success rates," said Kem F. Phillips at Advanced Biologics LLC in Lambertville,...

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