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Tobacco Use

Nicorette may be more efficient nicotine delivery system than Nicopatch

Published in Medical Letter on the CDC and FDA, April 13th, 2003

Testing showed that Nicorette was a more efficient nicotine delivery system than Nicopatch, however, the testing methodology may be flawed.

According to a study from France, "The aim of this work was to compare in vitro the performances at delivering nicotine of two transdermal delivery system (TDS): Nicorette (8.3 mg/10 cm2 nicotine content) and Nicopatch (17.5 mg/10 cm2)."

"Release profiles were obtained using the FDA paddle method, and skin permeation profiles using Franz-type diffusion cells," reported Jean-Christopher Olivier and colleagues at the Faculte de Medecine et de Pharmacie. "Using the first method, nicotine...

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