Diabetes Genomics and Genetics
Gly482Ser mutation associated with early insulin secretion in Pima Indians
Published in Medical Letter on the CDC and FDA, April 27th, 2003
"Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) is a transcriptional coactivator of peroxisome proliferator-activated receptor gamma and alpha, which play important roles in adipogenesis and lipid metabolism. A single nucleotide polymorphisin within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population. In this study, we examined whether this...
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