Enzymology
New data indicate separase mitotic exit function separate from protease activity
Published in Medical Letter on the CDC and FDA, April 27th, 2003
According to recent research from the United States, "Separase is a conserved protease that activates the metaphase-to-anaphase transition by cleaving the link between sister chromatids. Furthermore, in Saccharomyces cerevisiae, separase is also involved in promoting mitotic exit through regulating Cdc14 release."
"A new study now suggests that the mitotic exit function of separase is independent from its protease activity," wrote Karen E. Ross and Orna Cohen-Fix, at the National Institute of Diabetes and Digestive and Kidney...
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