Attention Deficit Hyperactivity

Variation in activity levels in rat strains limit their usefulness

Published in Medical Letter on the CDC and FDA, May 25th, 2003

The variations in short- and long-term activity levels in spontaneously hypertensive, Wistar-Kyoto, and Sprague-Dawley rats limit their usefulness in investigations into attention deficit hyperactivity disorder.

According to a study from the United States, "The pattern of locomotor activity across development was assessed in male and female spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), and Sprague-Dawley (SD) rats."

"Open field activity did not indicate hyperactivity in the SHR," reported Sherry A. Ferguson and Amy M. Cada at the U.S. Food and Drug Administration. "Instead, the SD strain was generally more active. Strains and sexes did not...

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Source: Medical Letter on the CDC and FDA (2003-05-25)

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