Polio Vaccine
Poliovirus is excreted in feces of poliovirus receptor-transgenic mice
Published in Medical Letter on the CDC and FDA, August 3rd, 2003
"The emergence of circulating vaccine-derived poliovirus (cVDPV) strains in suboptimally vaccinated populations is a serious threat to the global poliovirus eradication. The genetic determinants for the transmissibility phenotype of polioviruses, and in particularly of cVDPV strains, are currently unknown. Here we describe the fecal excretion of wild-type poliovirus, oral polio vaccine, and cVDPV (Hispaniola) strains after intraperitoneal injection in poliovirus receptor-transgenic mice," researchers in Netherlands report.
"Both the...
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