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Genomics and Genetics

Frequency of TNF genes in African Americans from southeast U.S. determined

Published in Medical Letter on the CDC and FDA, August 17th, 2003

Investigators have determined the allele frequencies of human leukocyte antigen (HLA) class II and tumor necrosis factor (TNF) genes in African Americans from the Southeastern United States.

According to recent research published in the journal Human Immunology, "Knowledge of population major histocompatibility complex gene frequencies is important for construction of organ donor pools and for studies of disease association."

"Human leukocyte antigen DRB1 (HLA-DRB1), HLA-DQB1, and TNF-alpha-308 (G-A) promoter genetic typing was performed in 112 healthy, unrelated African Americans (AAs) from the southeastern United States," reported Tamara...

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