Drug Adverse Effects

Fenfluramine and methylenedioxymethamphetamine induce serotonergic changes

Published in Medical Letter on the CDC and FDA, August 24th, 2003

Scientists reported the plasma levels at which d-fenfluramine and 3,4-methylenedioxymethamphetamine induce serotonergic alterations in monkeys.

According to a study from the United States, "Plasma levels of parent compounds and metabolites were determined in adult rhesus monkeys after doses of either 5 mg/kg d-fenfluramine (FEN) or 10 mg/kg d-3,4-methylenedioxymethamphetamine (MDMA) i.m. twice daily for four consecutive days."

"These treatment regimens have been previously shown to produce long-term serotonin (5-HT) depletions," stated John F. Bowyer and collaborators at the Food and Drug Administration, University of Miami, and Glaxo Wellcome. "Peak...

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Source: Medical Letter on the CDC and FDA (2003-08-24)

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