Animal Models
Neurotoxicity of trimethyltin differs among rat strains
Published in Medical Letter on the CDC and FDA, August 31st, 2003
According to recent research published in the journal Neurotoxicology and Teratology, "Strain differences represent an overlooked variable that may play an important role in neurotoxic outcomes that can impact regulatory decision making. Here, we examined the strain-dependent effects of trimethyltin (TMT), a compound used as a positive control for behavioral and neurochemical assessments of neurotoxicity."
"Adult male Long-Evans (LE) and Fischer 344 (F344) rats (n=12 each) were trained to respond under a multiple, fixed-interval three-minute fixed-ratio...
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