Tick-borne Disease
Outer surface protein C primed mice not protected against Borrelia burgdorferi
Published in Medical Letter on the CDC and FDA, September 14th, 2003
According to a study from the United States, "A one-inoculation regimen of recombinant outer-surface protein C (OspC), which has been demonstrated to elicit protective immunity against a tick-borne challenge of Borrelia burgdorferi, was administered to outbred mice. Following seroconversion, the serum antibody titer against OspC was allowed to wane with time until there was little or no detection of anti-OspC antibodies by immunoblot. The mice were then challenged with an infectious dose of B....
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