Bacteriology

Brucella abortus induces TNF and IL-12p40 by MyD88-dependent pathways

Published in Medical Letter on the CDC and FDA, September 21st, 2003

Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways.

"Cattle and humans are susceptible to infection with the Gram-negative intracellular bacterium Brucella abortus. Heat-killed B. abortus (HKBA) is a strong Th1 adjuvant and carrier," scientists writing in the Journal of Immunology report.

"Previously, we have demonstrated that dendritic cells produce IL-12 in response to HKBA stimulation," stated Li-Yun Huang and collaborators at the Centers for Disease Control and Prevention, National Cancer Institute, and the University of Massachusetts. "In the present study, we use knockout mice...

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Source: Medical Letter on the CDC and FDA (2003-09-21)

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