DNA Damage

DNA damage control in cells exposed to ionizing radiation reviewed

Published in Medical Letter on the CDC and FDA, October 26th, 2003

Researchers have published a review of DNA damage checkpoint control in cells exposed to ionizing radiation in a recent issue of the journal Oncogene.

According to a study from Germany and the United States, "Damage induced in the DNA after exposure of cells to ionizing radiation activates checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and induce a transient delay in the progression through S phase. Checkpoints together with repair and apoptosis are integrated in a circuitry that determines the ultimate response of a cell to DNA damage."

"Checkpoint activation typically requires sensors and mediators of DNA...

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Source: Medical Letter on the CDC and FDA (2003-10-26)

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