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Smallpox

Orthopoxviruses detected using microarrays of immobilized oligonucleotides

Published in Medical Letter on the CDC and FDA, November 16th, 2003

Researchers report the detection and discrimination of orthopoxviruses using microarrays of immobilized oligonucleotides.

"Variola virus (VARV), causing smallpox, is a potential biological weapon. Methods to detect VARV rapidly and to differentiate it from other viruses causing similar clinical syndromes are needed urgently. We have developed a new micro array-based method that detects simultaneously and discriminates four orthopoxvirus (OPV) species pathogenic for humans (variola, monkeypox, cowpox, and vaccinia viruses) and distinguishes them from chickenpox virus (varicella-zoster virus or VZV)," scientists in the United States and Russia report.

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