Medical Letter on the CDC and FDA
Susan Hasty, Publisher
Table of Contents . . . December 14th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Breast Cancer - Mechanisms of Taxol resistance related to microtubules reviewed
Cancer Therapy - IL-4-Pseudomonas exotoxin protein used for malignant glioma therapy
Dengue Fever - Dengue 2 PDK-53 virus used as chimeric carrier for dengue vaccine
Tuberculosis - CD4+ T cells mediate IFN-gamma-independent control of M. tuberculosis
AIDS Epidemiology - Fewer AIDS babies born in U.S. but worldwide transmissions remain epidemic
AIDS Testing - VScan maker receives IRB approval for live testing
Aging - Testosterone research strategies outlined by IOM
Amyotrophic Lateral Sclerosis - Company receives orphan drug designation for ALS drug candidate
Anthrax - Pathology is critical in investigation of cutaneous anthrax
Bradycardia - Company receives U.S. approval of INSIGNIA Ultra pacemaker
Breast Cancer - Incidence of unusually large tumors increased in 1990s
Cancer Epidemiology - Report shows prostate leading cancer among men, breast cancer leads for women
Cancer Screening - Elderly women overscreened for cancers with little measurable benefit
Candidiasis - Method to distinguish among Candida species developed
Chemogenomics - Company provides model drug submission to FDA
Diabetes Epidemiology - Incidence of diabetes in developing nations may double
Drug Development - Improved testing of linearity for analytical methods developed
Drug Review - FDA's fast track initiative cut development time by 3 years
Ebola - Human trials start on Ebola vaccine
Environmental Toxins - Feds worried about playground-cancer link
Finance - Company reports revenue of $23.6 million in Q3, provides updates on Erbitux
Gastroenterolgy - Norwalk virus mRNA 3' end regulates VP1 expression via VP2
Gene Mutations - Muse lymphoma thymidine kinase gene mutation assay evaluated
HIV/AIDS Diagnosis - Newly approved rapid HIV-1 test is really rapid
HIV/AIDS Therapy - Early SHIV control in monkeys causes long-lasting asymptomatic outcomes
Heart Pumps - Site selection nears completion for trial of DeBakey VAD for destination therapy
Hematology - Diamond Blackfan anemia stem cells fail to repopulate erythropoiesis
Hepatitis A Virus - Consumers advised that recent outbreaks have been associated with green onions
Imaging - Company obtains FDA approvable letter for mammography CAD
Immunology - CpG oligodeoxynucleotides need second receptor or cofactor to signal
Immunology - G protein coupled receptors allow manipulation of inflammation in vivo
Infectious Disease - Cryptococcus recombination event may underlie Vancouver Island outbreak
Infectious Disease Diagnostics - Real-time PCR improves respiratory syncytial virus infection diagnosis
Influenza - Early evidence suggests current flu season could be severe
Injury Prevention - Culture affects links drawn between alcohol and injury
Insomnia - FDA extends PDUFA action date for Estorra NDA
Leishmaniasis - Histone H1 antigen protects against cutaneous leishmaniasis in monkeys
Leukemia Therapy - Gemtuzumab ozogamicin treatment of acute myeloid leukemia promising
Malignant Glioma - IL-13 cytotoxin used for malignant glioma therapy
Minority Health - Haircuts and healthcare offered at black men's clinic
Mitral Regurgitation - Myocor presents valve repair abstract, begins Coapsys trial
Mumps Virus - Changes in mumps virus gene sequence linked to phenotype variability
Nicotine Addiction - Study: High school students smoking less
Obesity Epidemiology - Tracking in epidemiologic studies exemplified by obesity study
Obesity Epidemiology - Weight loss programs needed for obese adolescents in Latin America
Occupational Health - DNA adducts from lung tissue of asphalt fume-exposed mice characterized
Osteoporosis - Fracture risk reduction after osteoporosis treatment outlined
Papillomavirus - Peak HPV seropositivity occurs after DNA positivity; duals have high cancer risk
Patents - Patent office allows additional patent claims to STR for cancer therapy
Patents - Patents issued for carbohydrate drug targeting and delivery platforms
Prescription Drug Importation - U.S. wants Canada to better regulate Internet pharmacies
Prostate Cancer - Study finds racial differences in survival rates after treatment
Public Health - CDC launches SMART project on local-level health risk data
Pulmonary Embolism - Gunther Tulip Vena Cava Filter receives FDA clearance for retrievability
Regulatory Issues - NCI, FDA announce two new initiatives as part of strategic partnership
Rheumatoid Arthritis - Phase IIb clinical trials of Pralnacasan discontinued due to toxicity
SARS - High pollution may increase death rate
SARS - Respiratory disease could come back, CDC head says
Smallpox - Studies describe heart disease following vaccination
Smallpox Vaccine - Eosinophilic-lymphocytic myocarditis proven after smallpox vaccination
Smallpox Vaccine - Safer smallpox vaccination regimen modeled for HIV-1-infected patients
Streptococcus - Streptococcal protein GB1 mutation causes large molecular conformation changes
Tachyarrhythmia - ENDOTAK RELIANCE G leads get FDA nod
Toxicology - Glucuronidation patterns of monoester phthalate metabolites reported
Vertebral Compression Fractures - FDA grants investigational device exemption for bone void filler clinical study
West Nile Virus - Company gets $4.3 from NHLBI to pursue licensure of WNV nucleic acid test
West Nile Virus - West Nile/dengue virus vaccine protect monkeys from West Nile virus
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