Dengue Fever

Dengue 2 PDK-53 virus used as chimeric carrier for dengue vaccine

Published in Medical Letter on the CDC and FDA, December 14th, 2003

The dengue 2 PDK-53 virus has been used as a chimeric carrier for tetravalent dengue vaccine development.

"Attenuation markers of the candidate dengue 2 (D2) PDK-53 vaccine virus are encoded by mutations that reside outside of the structural gene region of the genome. We engineered nine dengue virus chimeras containing the premembrane (prM) and envelope (E) genes of wild-type D1 16007, D3 16562, or D4 1036 virus within the genetic backgrounds of wild-type D2 16681 virus and the two genetic variants (PDK53-E and PDK53-V) of the D2 PDK-53 vaccine virus," scientists in the United States and Thailand report.

"Expression of the heterologous prM-E genes in...

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Source: Medical Letter on the CDC and FDA (2003-12-14)

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