Tuberculosis

CD4+ T cells mediate IFN-gamma-independent control of M. tuberculosis

Published in Medical Letter on the CDC and FDA, December 14th, 2003

CD4+ T cells mediate IFN-gamma-independent control of Mycobacterium tuberculosis infection both in vitro and in vivo.

According to recent research published in the Journal of Immunology, "Although IFN-gamma is necessary for survival of Mycobacterium tuberculosis infection in people and animal models, it may not be sufficient to clear the infection, and IFN-gamma is not a reliable correlate of protection. To determine whether IFN-gamma-independent mechanisms of immunity exist, we developed a murine ex vivo culture system that directly evaluates the ability of splenic or lung lymphocytes to control the growth of M. tuberculosis within infected...

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Source: Medical Letter on the CDC and FDA (2003-12-14)

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