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Medical Letter on the CDC and FDA

Susan Hasty, Publisher

Table of Contents . . . December 21st, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications

Alcoholism - Many barriers exist to the use of medications for treating alcoholism

HIV/AIDS Therapy - HIV infection inhibited by cyclophilin from Toxoplasma gondii

Drug Development - Biopharmaceuticals becoming larger portion of drugs developed

Immunotherapy - Risks associated with use of intravenous immunoglobulin reviewed

Policy - Records link patients and disease for future policy implementation

Tobacco Use - Females especially susceptible to tobacco-related problems

AIDS Epidemiology - U.N.: Global AIDS epidemic rampant

AIDS Funding - Five-year, $1.5 million grant to fight spread of HIV/AIDS and TB in Africa

Acne - Company reports efficacy from phase IIb acne study

Allergy Medicine - Recent studies reduce need for pediatric studies of allergy medications

Angioedema - Icatibant gets orphan drug designation

Angioplasty - FDA updates information for physicians on Cypher stent

Antibiotics - Company updates timing of oritavancin NDA submission

Antimicrobial Resistance - Drug resistance linked to location and emm type of Streptococcus

Attention Deficit/Hyperactivity Disorder - ANDA filed for generic version of Adderall

Bacterial Contamination - Salmonellae can be concentrated from liquids by using an immunoaffinity column

Bioengineering - Mini-lambda presents a flexible system for in vivo genome engineering

Burn Medicine - Bacterial toxicosis contributes to morbidity in children with burns

Candidiasis - Vfend receives FDA approval for treatment of esophageal candidiasis

Cell Therapy - Tissue regeneration company shows positive results in the U.K.

Cholesterol - Ezetimibe acts as selective cholesterol absorption inhibitor

Contraception - FDA approves Ovcon 35 chewable birth control tablets

Contraception - FDA considers over-the-counter "morning after" pill

Contraception - New oral contraceptive marketed to healthcare providers

Corporate Update - Company provides overview of drug-eluting stent program

Correction - Supplement filed for approval of needleless device used with Kogenate FS

Dengue Fever - Dengue virus infects cells by viral envelope binding to polypeptides

Depression - Suicidal minority teens lack adult support

Dermatology - Approval granted for generic mometasone ointment

Diagnostics - HPLC method validated for determination of ranitidine in plasma

Disease Resistance - Scientists explore why most breastfed infants of HIV+ mothers resist infection

Environmental Toxins - New web site to screen for lead poisoning

Erectile Dysfunction - FDA approves third drug to treat ED

Esophageal Candidiasis - FDA approves Vfend for fungal infection

Food-borne Illness - Government report says salmonella declining in raw meat

Food-borne Illness - Report: Georgia, North Carolina hepatitis strains linked

Food-borne Illness - USDA announces unified food safety research agenda

Gastric Ulcer - Prevacid NapraPAC granted FDA approval

Generic Drugs - Filing for generic version of Adderall XR accepted by FDA

HIV Antibodies - Additional data submitted to FDA for oraquick HIV-2 claim

HIV Diagnosis - Pros and cons of HIV testing in less developed countries discussed

HIV Epidemiology - HIV transmission within the U.K. is increasing

HIV Epidemiology - New study shows overall increase in U.S. HIV diagnoses

Head Injury - Drug company stakes future on medicines from marijuana compounds

Heart Failure - Incara and Indevus outlicense bucindolol

Hematology - ABO blood type and race affects von Willebrand factor activity

Hives - FDA approves over-the-counter Claritin for hives treatment

Hypertension - Diorganotin(IV) complexes with captopril characterized

Infectious Disease - Serum albumin level linked to HFRS severity

Influenza - U.S. is poorly prepared for influenza pandemic, experts warn

Influenza - Worst flu season in 30 years predicted

Injury Prevention - Higher speed limits have translated to more deaths

Malaria Pathogenesis - Extracellular PSAC lysines involved in Na+ exclusion

Meningococcal Vaccine - Right decisions in public health based on science and expertise

Mental Health - High-cost Medicaid enrollees have more serious mental health disorders

Migraine Headache - FDA issues approvable letter for migraine prophylaxis indication for Topamax

Morphine Addiction - The GABA(B) receptor agonist baclofen inhibits opiate-induced reward effect

Multifunctional Receptors - Melanocortin 1 receptor is induced by alpha melanocyte stimulating hormone

Nosocomial Infection - Novel norovirus strain responsible for gastroenteritis outbreak in Swiss university hospital

Nosocomial Infection - Revised standards approved to prevent deadly healthcare-associated infections

Orthopedics - Volumetric CT evaluates therapy efficacy of peri-prosthetic osteolysis

Outbreaks - Contaminated fountain blamed for Pontiac fever outbreak in Tennessee

Parasitic Disease - Fascioliasis risk is high among women and schoolchildren in the Nile Delta

Pediatric AIDS - Children's genetic factors determine HIV progression

Pediatrics - School children in Cameroon harbor a variety of parasites

Policy - Group releases workforce report with new sense of urgency

Postoperative Pain - Pharmaceutical company seeks U.K. approval of DepoMorphine

Prion Disease - Therapies for transmissible spongiform encephalopathies reviewed

Prostate Cancer - FDA approves new drug for advanced prostate cancer

Proteomics -  Schizosaccharomyces pombe Ras1 effector mediates cytokinesis

Proteomics - Clinical development of FGF-2 for therapeutic angiogenesis has limited success

Pseudomonas - FDA grants approval for Piperacillin injection

Regulatory Issues - Federal proposal alarms infertility community

Rheumatoid Arthritis - Costs calculated for arthritis, other rheumatoid diseases

Rheumatoid Arthritis - IND application filed for AME-527

SARS - China to test experimental vaccine

SARS - Dealing with emerging infectious diseases requires vigilance

Salmonella - orgC gene product of Salmonella enterica characterized

Smallpox - Company licenses technology from NIAID for vaccine for smallpox

Smoking Cessation - Study shows strong tobacco control programs and policies can lower smoking rates

Stents - Cobalt-alloy biliary stent now available in the United States

Syphilis - Screening for STD should be routine part of medical care for people with HIV

Syphilis - U.S. syphilis rate climbs for second consecutive year

Terrorism - $5M equipment order to help CDC improve response to terrorism

Tetanus - Gates Foundation gives $10 million to U.N. fight against deadly maternal tetanus

Toxoplasmosis - Complete cross-reactivity found in Toxoplasma gondii isolates

Transplant Medicine - Solitary pancreas transplant not associated with improved survival for diabetics

Trial Compliance - Med-eMonitor clinical trial data presented at FDA/Drug Information Association conference

West Nile Virus - Professor wins CDC grant to combat emerging infections

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